Dr. Mario & Bacteria Extermination is a puzzle video game starring Dr. Mario in development for WiiWare, a service launching for Nintendo's Wii in Japan in March 2008.
The title supports the Nintendo Wi-Fi Connection service, allowing players to compete with one another over the Internet. Players can also use their Mii characters instead of Mario characters during gameplay. Dr. Mario & Bacteria Extermination also features a version of the Nintendo DS title Brain Age 2's "Virus Buster/Germ Buster" mini-game, which now allows up to four players to participate cooperatively.