I'd imagine most of you are familiar with the Xbox 360 title, Dead Rising. (seen below.)
Imagine playing this on the Wii.
Using the Nunchuk to control your movement and the remote to swing your weapons, I think this could be great fun, and would tap well with some of Nintendo's more mature audience.
I know this will never happen, as the game is partially made by Microsoft, but something like it would be nice.