Originally Posted by Zori
If you think you know the Resident Evil storyline after playing 4, think again. Resident Evil 4 in no way follows the storyline, it's set somewhere in Europe (not America) and is based on the Las Plagas virus or something like that which doesn't even turn the people into zombies, but weapon wielding freaks.
I seriously suggest you play games 1-3, then you will know more. If you're quick you could do them all in 24 hours.