I can't really call myself a huge football fan (I can watch a few games and not get bored, that's as much as I can say), and I haven't really owned a Madden title before (only played it at friends' houses), but it's a fun title for the Wii.
If you ever remotely liked a madden title before, I'd say you're pretty much obligated to get it for the wii. Otherwise it's worth at least checking out.
The multiplayer modes are pretty good, and I end up playing 2 on 2 and kicking combine (not available on other ports) the most at my house. They're really fun and kicking combine gets pretty crazy when you get a full 4 player game (/laugh at a 50mph wind against the kicker). As for head to head play or even single player, the sensor controllers nonetheless give a more satisfying experience when you earn that big yard gain or stop.
Small shame that there is no online play (though it did at least present an interesting easter egg via forecast channel sync), but it's always more fun to smack talk them face to face, anyway.