Resident Evil 4 - Wii Edition has been confirmed:
This should not be confused with the brand new RE Wii game, Resident Evil - The Umbrella Chronicles, due out at a later date. This is a reworking of RE4 for the Wii...
"Accordingly, RE4 will make full use of the Wiimote. During close-range attacks, the motion-sensitive controller should be shaken, Leon will automatically detect the enemy and perform a knife attack.
Likewise, the Wiimote will also be used to aim a targetting cursor in order to shoot and fire at your enemies. Hold down the "B" button and shake it a bit to reload your ammo. The built-in speaker will also sport a reload sound effect."