I'd like to see game developers include left handed options ,sort of like whats done in Wii-Sport .
For example - Prince of Persia , the controls would be basically the same , but the Wii-mote would gesture for the left hand and the Nun-chuck would gesture for the right hand .
Or how about left hand side weapon animations in an FPS . Although I can't see this having any real benefit on game play past aesthetics , It may give us lefties more of a sense of holding the weapon . And spent cartridge cases flying across the screen would look really cool .