Since this is a problem within a game, I thought I'd post this here.
I was playing Big Brain Academy and got to expert level in Balloon Bash and out of the blue the pointer turned upside down and responded opposite from what it should have. I managed to get the system turned off and turned it back on, and the pointer works fine on the regular menu and in other games, but in Big Brain its upside down and will not rotate. I can still point and click, so the game isn't entirely useless now but the remote won't rotate or flip over. Anyone have an idea how to fix this without resetting the whole console?