Just a story here, I got Medal of Honor 2: Heroes the other night, was SO hyped to play......put it in, and my Wiimote instantly screwed up.......I noticed this barely on other games, but it made MOH2 IMPOSSIBLE to play....jumping around when I got to the right side of the screen, pointer disappears, etc.........of course, first thing i think, resync.......so I did, both remotes, same problem........searched the message boards, nothing, so resync again to be sure, nothing. Because MOH relies on precise pointing (as opposed to Tiger '08 or something) is was impossible to even play the game.
So then I spot something, and do a quick test.....CHRISTMAS TREE LIGHTS......the tree is next to the TV, on the right side....we've heard that neon, etc interferes with the Wiimotes, but so do christmas lights apparently. I turned them off, and wham, game played perfectly, and I became the proud owner of a sore hand due to 5 hours of straight online play, awesome awesome game
So, if anyone else is having this problem with a Wiimote, and you have a Christmas tree near your Wii, try turning it off, might be the problem