Thanks for the comments. I guess what the problem is that on my 32" the cursor was perfectly lined up with the Wii gun for shooting games (mostly MoHH2). Anywhere I pointed on the screen was perfectly matched by the pointer. Now, with the bigger TV, it's off by a few degrees, and it's bugging me. Sure I can get used to it, and it will be far less relevant for other types of games, but I thought I'd check to see if this is a problem that others have.
One other thing (that might help): I cannot currently select 1080i as my TV resolution. I'm assuming it's because I have not yet plugged in the component cables. I presume this may help the issue by telling the Wii "how big" my TV is. Is it true that the option will appear when I get those cables?