Metroid Prime is technically a different series (hence, a trilogy). You can't compare them to say, Other M.
A new Metroid Prime Trilogy, perhaps?
L.A. Noire Wii U style, would be awesome. I also hope more of Rockstar Games brings they games out for the Wii U. And I hope Nintendo gets an open marked for game development (like sony).
That be cool using the tablet to find clues and etc...
They need to bring back Castlevania judgement from the ashes. They did it with Red Steel 2.
^Or.... bring back the GOOD castlevania games. Like Super Castlevania, before they went anime.
A Neon Genesis Evangelion game in the vibe of Neon Genesis Evangelion for the Nintendo 64.
My Wii U wishlist, it's a long one...
Super Mario Galaxy 3
New Super Mario Bros Mii
Donkey Kong Country Returns 2
Wii U Play
Monster Hunter 4/5
Resident Evil 6
Ninja Gaiden 3
Tatsunoko vs Capcom 2
No More Heroes 3
Fatal Frame 5
If half of those came out for Wii U I'd be very happy. The games that seem like they'd make the best use of the controller would be the Capcom ones, as they often have awkward inventory/menu systems that could be put on the touchscreen instead. It would make the Wii U versions of games like Monster Hunter or Resident Evil more appealing just for that alone. Best of all would be Fatal Frame, using the controller's visual overlay as your camera obscura would be incredibly awesome (doubt that we'll get it though).