Distant Oblivion started the Harvest Moon Thread, which would be AMAZING. Harvest Moon is one of my favorite series, but putting it on the Wii would give it a whole new gameplay facelift.
I'm holding out for a game that using the Wii controller as a means of precisely controlling a sword or axe, like a MorrowWind type game in first person. Instead of clicking a mouse to swing , you get to do it and this leaves the oppurtunity to create for technically difficult bosses and enemies. Just a thought.