The last few times beating re4 on wii , my newest strategy has been to upgrade the regular rifle all the way and not buy the sexier semi-auto version. Reason being the regular rifle has 12 more firepower (a whopping 30 overall) than the semiauto when fully upgraged, making it the 2nd most powerful non-super weapon. This strategy works espeacially well when facing regenerators because with the fully upgraded regular rifle it only takes about 7 shot to kill them , so I just sell the space consuming infared scope for a nice profit and dispose of the regenerator with my regular rifle in 7 shots. If your good with a rifle then try this strategy out its pretty cool. The load times are a *****, but 30 firepower is pretty devastating.